Warner Lab
Margaret Warner, Ph.D.
Professor
Department of Biology and Biochemistry
Office: SERC, 3021
Contact: mwarner@uh.edu - 832-842-8812
Professor Margaret Warner leads a research group focused on the study of three soluble ligand- activated receptors - estrogen receptor beta (ERβ) and liver X receptor beta (LXRβ) in health and disease.
Studies with ERβ led to the discovery of a pathway in which dihydrotestosterone is converted into 3β-Adiol, an ERβ agonist. The pathway revealed a novel role for dihydrotestosterone in the prostate i.e., in addition to being a potent androgen, it is a precursor of an estrogen.
On the basis of the phenotype of mice in which ERβ or LXRβ have been inactivated, the team is investigating the value of ERβ as a target for treatment of breast and prostate cancer.
Both receptors are involved in regulation of the immune system. Both ERβ and LXRβ play key roles in the central nervous system and appear to offer protection against neurodegenerative diseases caused by over activity of the brain’s immune system. These include Parkinson’s disease, Amyotropic lateral sclerosis and Multiple sclerosis.
Prior to joining the Center, Warner worked in close collaboration with professor Jan-Åke Gustafsson at the Karolinska Institute in Stockholm, Sweden. Warner is a member of the CNRCS founding faculty and shares a research group with Gustafsson.
One long-term collaborator in the team is neurobiologist, Wanfu Wu, a research assistant professor.
Margaret Warner, Ph.D.
Professor
Department of Biology and Biochemistry
色花堂
Houston, Texas 77204-5056
Office: SERC 545, Room 3021
Phone: 832-842-8812
mwarner@uh.edu
Research Faculty
Wanfu Wu
Research Assistant Professor
wwu@uh.edu
Wanfu Wu joined the Center as a postdoctoral fellow in the Gustafsson group. His experience includes working as a neuroscience researcher at the Chongqing Medical University, China, where he focused on the treatment effect of neural stems cells transfected with HIF-1a gene on ischemic stroke in rats. Wu also focused on the migration mechanism of neural stem cells after ischemic stroke. He has a Ph.D. in neuroscience and training in biochemistry, molecular biology, cell biology and immunology techniques.
| Publications on ERβ in the Prostate | Impact Factor |
|---|---|
| Wu WF, Maneix L, Insunza J, Nalvarte I, Antonson P, Kere J, Yu NY, Tohonen V, Katayama S, Einarsdottir E, Krjutskov K, Dai YB, Huang B, Su W, Warner M, Gustafsson JÅ. Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3816-E3822. doi: 10.1073/pnas.1702211114. PMID:28439009 | 9.4 |
| Maneix L, Antonson P, Humire P, Rochel-Maia S, Castañeda J, Omoto Y, Kim HJ, Warner M, Gustafsson JÅ.Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5135-40. doi: 10.1073/pnas.1504944112. PMID:25848008 | 9.4 |
| Kim HJ, Andersson LC, Bouton D, Warner M, Gustafsson JA.Proc Natl Acad Sci U S A. 2009 106(2):558-63doi:10.1073/pnas.0811295106 | 9.4 |
| Imamov O, Morani A, Shim GJ, Omoto Y, Thulin-Andersson C, Warner M, Gustafsson JA. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9375-80 | 9.4 |
| Weihua Z, Lathe R, Warner M, Gustafsson JA. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13589-94. PMID:12370428 | 9.4 |
| Weihua Z, Makela S, Andersson LC, Salmi S, Saji S, Webster JI, Jensen EV, Nilsson S, Warner M, Gustafsson JA. Proc Natl Acad Sci U S A. 2001 98(11):6330-5. | 9.4 |
| Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA, Smithies O.Proc Natl Acad Sci U S A. 199895(26):1567782.PMID:9861029 | 9.4 |
| Papers on ERβ in Tissues Other Than the Prostate Jan 2014–Present | Impact Factor |
|---|---|
| D'Errico F, Goverse G, Dai Y, Wu W, Stakenborg M, Labeeuw E, De Simone V, Verstockt B, Gomez-Pinilla PJ, Warner M, Di Leo A, Matteoli G, Gustafsson JA. Proc Natl Acad Sci U S A. 2018 115(22):5798-5803. doi: 10.1073/pnas.1720267115. PMID:29760072 | 9.4 |
| Zhao L, Huang S, Mei S, Yang Z, Xu L, Zhou N, Yang Q, Shen Q, Wang W, Le X, Lau WB, Lau B, Wang X, Yi T, Zhao X, Wei Y, Warner M, Gustafsson JÅ, Zhou S. Proc Natl Acad Sci U S A. 2018 115(16):E3673-E3681. doi: 10.1073/pnas.1803291115. PMID:29592953 | 9.4 |
| Cai Y, Tang X, Chen X, Li X, Wang Y, Bao X, Wang L, Sun D, Zhao J, Xing Y, Warner M, Xu H, Gustafsson JÅ, Fan X. Proc Natl Acad Sci U S A. 2018.115(12):E2725E2733.doi:10.1073/pnas. 1800184115.PMID:29507213 | 9.4 |
| Zhang X, Li S, Zhou Y, Su W, Ruan X, Wang B, Zheng F, Warner M, Gustafsson JÅ, Guan Y.Proc Natl Acad Sci U S A. 2017. doi: 10.1073/pnas.1700172114.PMID 28270609 | 9.4 |
| Miao YF, Su W, Dai YB, Wu WF, Huang B, Barros RP, Nguyen H, Maneix L, Guan YF, Warner M, Gustafsson JÅ. Sci Rep. 2016 6:38579. doi: 10.1038/srep38579.PMID:279221255.2 | 5.2 |
| Abdel-Khalik J, Yutuc E, Crick PJ, Gustafsson JÅ, Warner M, Roman G, Talbot K, Gray E, Griffiths WJ, Turner MR, Wang Y. J Lipid Res. 2017 58(1):267-278. doi: 10.1194/jlr.P071639.PMID:27811233 | 5.5 |
| Huang B, Omoto Y, Iwase H, Yamashita H, Toyama T, Coombes RC, Filipovic A, Warner M, Gustafsson JÅ. Proc Natl Acad Sci U S A. 2014 111(5):1933-8. doi: 10.1073/pnas.1323719111.PMID: 24449868 | 9.4 |
| Warner M, Huang B, Gustafsson JA.Trends Pharmacol Sci. 2017 Jan;38(1):92-99. doi: 10.1016/j.tips.2016.10.006. Review.PMID:27979317 | 12.1 |
| Huang B, Butler R, Miao Y, Dai Y, Wu W, Su W, Fujii-Kuriyama Y, Warner M, Gustafsson JÅ. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11883-11888. PMID: 27688768 | 9.4 |
| Papers on the Function of LXRβ | Impact Factor |
|---|---|
| Dai YB, Miao YF, Wu WF, Li Y, D'Errico F, Su W, Burns AR, Huang B, Maneix L, Warner M, Gustafsson JÅ. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7614-9. doi: 10.1073/pnas.1607590113. PMID:27335465 | 9.4 |
| Bao X, Cai Y, Wang Y, Zhao J, He X, Yu D, Huang J, Jing S, Du Z, Yang T, Warner M, Gustafsson JA, Fan X. Mol Neurobiol. 2017 Mar;54(2):1467-1481. doi: 10.1007/s12035-016-9737-1. PMID:26846362 | 5.0 |
| Miao Y, Wu W, Dai Y, Maneix L, Huang B, Warner M, Gustafsson JÅ. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14006-11. doi: 10.1073/pnas.1519358112. PMID:26504234 | 9.4 |
| Dai YB, Wu WF, Huang B, Miao YF, Nadarshina S, Warner M, Gustafsson JÅ. Mol Psychiatry. 2016 Jun;21(6):844-56. doi: 10.1038/mp.2015.133. PMID:26324101 | 13.2 |
| Xu P, Xu H, Tang X, Xu L, Wang Y, Guo L, Yang Z, Xing Y, Wu Y, Warner M, Gustafsson JA, Fan X.Mol Psychiatry. 2014 19(8):947-57. doi: 10.1038/mp.2014.60. PMID:24934178 | 13.2 |
| Dai YB, Tan XJ, Wu WF, Warner M, Gustafsson JÅ. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13112-7. doi: 10.1073/pnas.1210833109. PMID:22826221 | 9.4 |
| Gabbi C, Kong X, Suzuki H, Kim HJ, Gao M, Jia X, Ohnishi H, Ueta Y, Warner M, Guan Y, Gustafsson JÅ. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3030-4. doi: 10.1073/pnas.1200588109. PMID:22323586 | 9.4 |
| Kim HJ, Andersson LC, Bouton D, Warner M, Gustafsson JA.Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):558-63. doi: 10.1073/pnas.0811295106. PMID:19122149 | 9.4 |
| Gabbi C, Kim HJ, Hultenby K, Bouton D, Toresson G, Warner M, Gustafsson JA. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15052-7. doi: 10.1073/pnas.0808097105. PMID:18806227 | 9.4 |
| Fan X, Kim HJ, Bouton D, Warner M, Gustafsson JA. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13445-50. doi: 10.1073/pnas.0806974105. PMID: | 9.4 |
| Kim HJ, Fan X, Gabbi C, Yakimchuk K, Parini P, Warner M, Gustafsson JA. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2094-9. doi:10.1073/pnas.0711599105. PMID:18238900 | 9.4 |