Feng Lab - 色花堂

色花堂

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Center for Nuclear Receptors and Cell Signaling

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Feng Lab

Qin Feng, Ph.D.

Associate Professor
Department of Biology and Biochemistry

Office: SERC, 3009
Contact: qfeng4@central.uh.edu - 832-842-8824

Epigenetic Regulation of Gene Expression in HIV and cancer

Fig 1

Epigenetics is defined as the study of heritable changes caused by mechanisms other than alterations in the DNA sequence. Core histones, the fundamental units of chromatin structure, are subject to many types of post-translational modifications such as acetylation, methylation, phosphorylation, ubiquitination, crotonylation, etc. Depending on the types and locations, these modifications can regulate gene expression either positively or negatively. Aberrant gene expression caused by deregulated epigenetics is implicated in the initiation and progression of many diseases. Our work has mainly focused on transcriptional coregulators, including histone modifying enzymes and acetylated histone binding proteins. We aim to understand the molecular events that lead to aberrant regulation of gene expression in human diseases, such as AIDS and cancer, and ultimately develop novel therapeutic agents.

TDRD1 in prostate tumorigenesis

Fig 2

Tudor domain containing 1 (TDRD1) is a germ cell specific protein containing four Tudor domains, the signature domains that bind to methylated lysine or arginine. Under physiological condition, TDRD1 is solely expressed in testis and ovary, but not in any other tissues. However, its expression is detected in ~70% of primary prostate tumors, suggesting TDRD1 is important in prostate cancer development. This project aims to understand how TDRD1 contributes to prostate tumorigenesis.

Prostate cancer immunotherapy

Fig 3

Prostate cancer has an immunologically “cold” nature and is notoriously resistant to checkpoint blockade immunotherapy. This is likely due to low level of somatic mutations in prostate tumors. As a result, prostate cancer cells cannot be recognized by T cells as foreigners. We aim to develop PSMA-specific CAR-NK cells for prostate cancer treatment. Because PSMA (prostate-specific membrane antigen) is a cell membrane protein that selectively expresses in normal prostate and highly elevated in prostate tumors, the PSMA-specific CAR-NK cells can direct the cytotoxicity toward prostate cancer cells and therefore is a promising strategy to overcome the “cold” nature of prostate tumors.

Funding

色花堂   National Institute of Allergy and Infectious Diseases

Qin Feng

Qin Feng, Ph.D.
Associate Professor

Department of Biology and Biochemistry
色花堂
Houston, Texas 77204-5001

Office: SERC 545, Room 3009
Phone: 832-842-8824
qfeng4@central.uh.edu

Taevien Loa

Taevien Loa
Graduate Student

Aroshi Mitra

Aroshi Mitra
Graduate Student

amitra5@central.uh.edu

Salman Promon

Salman Promon
Graduate Student

Alumni

Amrita Barua

Amrita Barua
Graduate Student

abarua2@central.uh.edu

Yujing Gao

Yujing Gao, Ph.D.

Yali Han

Yali Han, M.S.
Researcher
yhan20@central.uh.edu

Hussain Kalavadwala

Hussain Kalavadwala

Tran V Nguyen

Tran V Nguyen
Intern

tvnguy77@cougarnet.uh.edu

Jacky Wu

Jacky Wu
Graduate Student

jwu50@central.uh.edu

Sharon Zachariah

Sharon Zachariah

Zheng Zhang

Zheng Zhang, M.D., Ph.D.

Tianyi Zhou

Tianyi Zhou
Graduate Student

tzhou7@central.uh.edu

  • Gao Y, Chen L, Han Y, Wu F, Yang WS, Zhang Z, Huo T, Zhu Y, Yu C, Kim H, Lee M, Tang Z, Phillips K, He B, Jung SY, Song Y, Zhu B, Xu RM, Feng Q. Commun Biol. 2020 Apr 7;3(1):165. doi: 10.1038/s42003-020-0898-0. PubMed PMID: 32265480.
  • Fu X, Pereira R, De Angelis C, Veeraraghavan J, Nanda S, Qin L, Cataldo ML, Sethunath V, Mehravaran S, Gutierrez C, Chamness GC, Feng Q, O'Malley BW, Selenica P, Weigelt B, Reis-Filho JS, Cohen O, Wagle N, Nardone A, Jeselsohn R, Brown M, Rimawi MF, Osborne CK, Schiff R. Proc Natl Acad Sci U S A. 2019 Dec 11;. doi: 10.1073/pnas.1911584116. PubMed PMID: 31826955; PubMed Central PMCID: PMC6936436.
  • Feng Q, He B. Front Oncol. 2019;9:858. doi: 10.3389/fonc.2019.00858. eCollection 2019. Review. PubMed PMID: 31552182; PubMed Central PMCID: PMC6738163.
  • Zhang Z, Nikolai BC, Gates LA, Jung SY, Siwak EB, He B, Rice AP, O'Malley BW, Feng Q. Nucleic Acids Res. 2017 Sep 19;45(16):9348-9360. doi: 10.1093/nar/gkx550. PubMed PMID: 28637181; PubMed Central PMCID: PMC5766202.
  • Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Mol Cell. 2017 Sep 7;67(5):733-743.e4. doi: 10.1016/j.molcel.2017.07.026. Epub 2017 Aug 24. PubMed PMID: 28844863; PubMed Central PMCID: PMC5657569.
  • Gates LA, Shi J, Rohira AD, Feng Q, Zhu B, Bedford MT, Sagum CA, Jung SY, Qin J, Tsai MJ, Tsai SY, Li W, Foulds CE, O'Malley BW.J Biol Chem. 2017 Sep 1;292(35):14456-14472. doi: 10.1074/jbc.M117.802074. Epub 2017 Jul 17. PubMed PMID: 28717009; PubMed Central PMCID: PMC5582839.
  • Nikolai BC, Feng Q. Cell Host Microbe. 2017 May 10;21(5):549-550. doi: 10.1016/j.chom.2017.04.012. PubMed PMID: 28494231; PubMed Central PMCID: PMC6484844.
  • Xiao L, Lanz RB, Frolov A, Castro PD, Zhang Z, Dong B, Xue W, Jung SY, Lydon JP, Edwards DP, Mancini MA, Feng Q, Ittmann MM, He B.Prostate. 2016 Oct;76(14):1271-84. doi: 10.1002/pros.23213. Epub 2016 Jun 8. PubMed PMID: 27272765.
  • Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B. Oncotarget. 2016 Jul 26;7(30):47891-47903. doi: 10.18632/oncotarget.10294. PubMed PMID: 27374105; PubMed Central PMCID: PMC5216986.
  • Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin L. J Clin Invest. 2016 Jul 1;126(7):2626-41. doi: 10.1172/JCI84637. Epub 2016 Jun 13. PubMed PMID: 27294523; PubMed Central PMCID: PMC4922719.
  • Zhang Z, Lanz RB, Xiao L, Wang L, Hartig SM, Ittmann MM, Feng Q, He B. Oncotarget. 2016 Jun 21;7(25):37993-38003. doi: 10.18632/oncotarget.9366. PubMed PMID: 27191272; PubMed Central PMCID: PMC5122366.
  • Yi P, Wang Z, Feng Q, Pintilie GD, Foulds CE, Lanz RB, Ludtke SJ, Schmid MF, Chiu W, O'Malley BW. Mol Cell. 2015 Mar 19;57(6):1047-1058. doi: 10.1016/j.molcel.2015.01.025. Epub 2015 Feb 26. PubMed PMID: 25728767; PubMed Central PMCID: PMC4369429.
  • He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N. Proc Natl Acad Sci U S A.2014 Dec 23;111(51):18261-6. doi: 10.1073/pnas.1421415111. Epub 2014 Dec 8. PubMed PMID: 25489091; PubMed Central PMCID: PMC4280633.
  • Feng Q, O'Malley BW. Steroids. 2014 Nov;90:39-43. doi: 10.1016/j.steroids.2014.06.008. Epub 2014 Jun 16. PubMed PMID: 24945111; PubMed Central PMCID: PMC4192004.
  • Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, Osborne CK, Schiff R, O'Malley BW. Cell Res. 2014 Jul;24(7):809-19. doi: 10.1038/cr.2014.71. Epub 2014 May 30. PubMed PMID: 24874954; PubMed Central PMCID: PMC4085766.
  • Foulds CE, Feng Q, Ding C, Bailey S, Hunsaker TL, Malovannaya A, Hamilton RA, Gates LA, Zhang Z, Li C, Chan D, Bajaj A, Callaway CG, Edwards DP, Lonard DM, Tsai SY, Tsai MJ, Qin J, O'Malley BW. Mol Cell. 2013 Jul 25;51(2):185-99. doi: 10.1016/j.molcel.2013.06.007. Epub 2013 Jul 11. PubMed PMID: 23850489; PubMed Central PMCID: PMC3900250.
  • Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B. Biochem Biophys Res Commun. 2013 May 3;434(2):357-62. doi: 10.1016/j.bbrc.2013.03.078. Epub 2013 Apr 6. PubMed PMID: 23567971; PubMed Central PMCID: PMC3763992.
  • He B, Kim TH, Kommagani R, Feng Q, Lanz RB, Jeong JW, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW. Endocrinology. 2011 Mar;152(3):1047-56. doi: 10.1210/en.2010-0732. Epub 2011 Jan 5. PubMed PMID: 21209023; PubMed Central PMCID: PMC3040048.
  • Feng Q, He B, Jung SY, Song Y, Qin J, Tsai SY, Tsai MJ, O'Malley BW. J Biol Chem. 2009 Dec 25;284(52):36167-74. doi: 10.1074/jbc.M109.065524. Epub 2009 Oct 20. PubMed PMID: 19843527; PubMed Central PMCID: PMC2794732.
  • Giamas G, Castellano L, Feng Q, Knippschild U, Jacob J, Thomas RS, Coombes RC, Smith CL, Jiao LR, Stebbing J. Nucleic Acids Res. 2009 May;37(9):3110-23. doi: 10.1093/nar/gkp136. Epub 2009 Apr 1. PubMed PMID: 19339517; PubMed Central PMCID: PMC2685087.
  • Fu J, Jiang J, Li J, Wang S, Shi G, Feng Q, White E, Qin J, Wong J. J Biol Chem. 2009 Mar 13;284(11):6832-40. doi: 10.1074/jbc.M808988200. Epub 2009 Jan 5. PubMed PMID: 19126541; PubMed Central PMCID: PMC2652261.
  • Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW. Mol Cell. 2008 Feb 29;29(4):465-76. doi: 10.1016/j.molcel.2007.12.030. PubMed PMID: 18313384; PubMed Central PMCID: PMC2293272.
  • He B, Feng Q, Mukherjee A, Lonard DM, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW. Mol Endocrinol. 2008 Feb;22(2):344-60. doi: 10.1210/me.2007-0400. Epub 2007 Oct 11. PubMed PMID: 17932104; PubMed Central PMCID: PMC2234581.
  • Wu RC, Feng Q, Lonard DM, O'Malley BW. Cell. 2007 Jun 15;129(6):1125-40. doi: 10.1016/j.cell.2007.04.039. PubMed PMID: 17574025.
  • Yu C, York B, Wang S, Feng Q, Xu J, O'Malley BW. Mol Cell. 2007 Mar 9;25(5):765-78. doi: 10.1016/j.molcel.2007.01.025. PubMed PMID: 17349961; PubMed Central PMCID: PMC1864954.
  • Fielenbach N, Guardavaccaro D, Neubert K, Chan T, Li D, Feng Q, Hutter H, Pagano M, Antebi A. Dev Cell. 2007 Mar;12(3):443-55. doi: 10.1016/j.devcel.2007.01.018. PubMed PMID: 17336909.
  • Feng Q, Yi P, Wong J, O'Malley BW. Mol Cell Biol. 2006 Nov;26(21):7846-57. doi: 10.1128/MCB.00568-06. Epub 2006 Aug 21. PubMed PMID: 16923966; PubMed Central PMCID: PMC1636757.
  • Li X, Lonard DM, Jung SY, Malovannaya A, Feng Q, Qin J, Tsai SY, Tsai MJ, O'Malley BW. Cell. 2006 Jan 27;124(2):381-92. doi: 10.1016/j.cell.2005.11.037. PubMed PMID: 16439211.
  • Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y. Cell. 2005 Apr 22;121(2):167-78. doi: 10.1016/j.cell.2005.02.020. PubMed PMID: 15851025; NIHMSID:NIHMS37210.
  • Im H, Park C, Feng Q, Johnson KD, Kiekhaefer CM, Choi K, Zhang Y, Bresnick EH. J Biol Chem. 2003 May 16;278(20):18346-52. doi: 10.1074/jbc.M300890200. Epub 2003 Feb 25. PubMed PMID: 12604594.
  • Min J, Feng Q, Li Z, Zhang Y, Xu RM. Cell. 2003 Mar 7;112(5):711-23. doi: 10.1016/s0092-8674(03)00114-4. PubMed PMID: 12628190.
  • Feng Q, Zhang Y. Curr Top Microbiol Immunol.2003;274:269-90. doi: 10.1007/978-3-642-55747-7_10. Review. PubMed PMID: 12596911.
  • Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y. Curr Biol. 2002 Jul 9;12(13):1086-99. doi: 10.1016/s0960-9822(02)00924-7. PubMed PMID: 12121615.
  • Feng Q, Wang H, Ng HH, Erdjument-Bromage H, Tempst P, Struhl K, Zhang Y. Curr Biol. 2002 Jun 25;12(12):1052-8. doi: 10.1016/s0960-9822(02)00901-6. PubMed PMID: 12123582.
  • Ng HH, Feng Q, Wang H, Erdjument-Bromage H, Tempst P, Zhang Y, Struhl K. Genes Dev. 2002 Jun 15;16(12):1518-27. doi: 10.1101/gad.1001502. PubMed PMID: 12080090; PubMed Central PMCID: PMC186335.
  • Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y. Mol Cell Biol. 2002 Jan;22(2):536-46. doi: 10.1128/mcb.22.2.536-546.2002. PubMed PMID: 11756549; PubMed Central PMCID: PMC139742.
  • Wang H, Huang ZQ, Xia L, Feng Q, Erdjument-Bromage H, Strahl BD, Briggs SD, Allis CD, Wong J, Tempst P, Zhang Y. Science. 2001 Aug 3;293(5531):853-7. doi: 10.1126/science.1060781. Epub 2001 May 31. PubMed PMID: 11387442.
  • Feng Q, Zhang Y. Genes Dev. 2001 Apr 1;15(7):827-32. doi: 10.1101/gad.876201. PubMed PMID: 11297506; PubMed Central PMCID: PMC312663.